NDLI: Genomic location and characterisation of MIC genes in cattle

Content Provider	Springer Nature Link
Author	Birch, James Juan Sanjuan, Cristina Guzman, Efrain Ellis, Shirley A.
Copyright Year	2008
Abstract	Major histocompatibility complex (MHC) class I chain-related (MIC) genes have been previously identified and characterised in human. They encode polymorphic class I-like molecules that are stress-inducible, and constitute one of the ligands of the activating natural killer cell receptor NKG2D. We have identified three MIC genes within the cattle genome, located close to three non-classical MHC class I genes. The genomic position relative to other genes is very similar to the arrangement reported in the pig MHC region. Analysis of MIC cDNA sequences derived from a range of cattle cell lines suggest there may be four MIC genes in total. We have investigated the presence of the genes in distinct and well-defined MHC haplotypes, and show that one gene is consistently present, while configuration of the other three genes appears variable.
Starting Page	477
Ending Page	483
Page Count	7
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	60
Issue Number	8
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-06-12
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Major histocompatibility complex MIC genes Cattle Allergology Cell Biology Gene Function Human Genetics Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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Genomic location and characterisation of MIC genes in cattle