NDLI: Mechanisms of Cytotoxicity by Cosmetic Ingredients in Sea Urchin Eggs

Content Provider	Springer Nature Link
Author	Amouroux, I. Pesando, D. ël, H. Girard, J. P.
Copyright Year	1999
Abstract	The acute cytotoxicities of four cosmetic ingredients: a preservative, imidazolidinylurea (IU) and three mild surfactants, cocamido propyl hydroxy sultaine (CAS), magnesium laureth sulfate (Mg LES), and decyl glucoside (APG) were studied using sea urchin eggs. The cellular targets of these compounds were identified by studying the effects on calcium homeostasis, intracellular pH, sodium and potassium contents, protein and DNA synthesis, and protein phosphorylation. These compounds inhibited the first cleavage of sea urchin eggs in a dose-dependent fashion with half maximal doses (IC50) from 30 μg/ml for Mg LES, 60 μg/ml for IU, 83 μg/ml for CAS, to above 400 μg/ml for APG. The time at which a compound showed the greatest toxicity to the cell cycle was definable for APG (between 20 and 50 min postfertilization) and IU (from fertilization to 50 min later); the other compounds being toxic throughout division. Compounds exhibited toxicity to a wide range of cellular targets. IU, the least toxic, mainly operates through inhibition of protein and DNA syntheses. CAS and Mg LES produced nonspecific cytotoxicity related to alterations of membrane and endomembrane permeabilities resulting in ionic disequilibrium (Na+, K+, Ca2+) and inhibition of intracellular storage of Ca2+. The APG effect mainly involved intracellular pH and DNA synthesis, a hypothesis suggested by the narrow postfertilization period of maximal toxicity.
Starting Page	28
Ending Page	37
Page Count	10
File Format	PDF
ISSN	00904341
Journal	Archives of Environmental Contamination and Toxicology
Volume Number	36
Issue Number	1
e-ISSN	14320703
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Medicine Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Appearance of New Glycoproteins in Methoxychlor-Exposed Sea Urchin Gastrulae

Estradiol Disrupts Sea Urchin Embryogenesis Differently from Methoxychlor

Effects of Methoxychlor Pre-Exposure on Sea Urchin Gametes

Effects of Cadmium and Phenol on Motility and Ultrastructure of Sea Urchin and Mussel Spermatozoa

Cytotoxicity of Methacrylonitrile

Comparison of Embryonic Development and Metal Contamination in Several Populations of the Sea Urchin Sphaerechinus granularis (Lamarck) Exposed to Anthropogenic Pollution

Metallic nickel nanoparticles and their effect on the embryonic development of the sea urchin Paracentrotus lividus.

Toxicity of Metals and Pesticides Using the Sperm Cell Bioassay with the Sea Urchin Arbacia spatuligera

Spermiotoxicity and Embryotoxicity of Permethrin in the Sea Urchin Paracentrotus lividus

Mechanisms of Cytotoxicity by Cosmetic Ingredients in Sea Urchin Eggs

Similar Documents

Appearance of New Glycoproteins in Methoxychlor-Exposed Sea Urchin Gastrulae

Estradiol Disrupts Sea Urchin Embryogenesis Differently from Methoxychlor

Effects of Methoxychlor Pre-Exposure on Sea Urchin Gametes

Effects of Cadmium and Phenol on Motility and Ultrastructure of Sea Urchin and Mussel Spermatozoa

Cytotoxicity of Methacrylonitrile

Comparison of Embryonic Development and Metal Contamination in Several Populations of the Sea Urchin Sphaerechinus granularis (Lamarck) Exposed to Anthropogenic Pollution

Metallic nickel nanoparticles and their effect on the embryonic development of the sea urchin Paracentrotus lividus.

Toxicity of Metals and Pesticides Using the Sperm Cell Bioassay with the Sea Urchin Arbacia spatuligera

Spermiotoxicity and Embryotoxicity of Permethrin in the Sea Urchin Paracentrotus lividus

Mechanisms of Cytotoxicity by Cosmetic Ingredients in Sea Urchin Eggs