NDLI: Biosensors of Inorganic Lead Exposure and Effect in an Adult Amphibian

Content Provider	Springer Nature Link
Author	Arrieta, Marcos A. Bruzzone, Liliana Apartín, Carina Rosenberg, Carolina E. Fink, Nilda E. Salibián, Alfredo
Copyright Year	2004
Abstract	Lead (Pb) is a ubiquitous environmental pollutant, widely distributed, representing a high toxicological and ecotoxicological risk. Several morphological, functional, and biochemical parameters have been proposed as biomarkers of effect and exposure to Pb. The information related to adverse effects of Pb is not abundant for adult amphibians. These animals are of interest, because during their development they move from aquatic to terrestrial habitats, which may be polluted by the metal since they are receptors of products generated by anthropogenic activities. Previous studies carried out on the adult South American toad Bufo arenarum (Amphibia, Anura) showed that it has a high tolerance to lead and studied the effect of sublethal doses of the metal on the erythrocyte osmotic fragility and δ-ALAD activity. It was also shown that after a single injection of Pb, a significant increase in the number of reticulocytes was produced, suggesting the suitability of those cell counts as a biomarker of exposure to the metal; its impact on the immune system of the toads was also studied. In this work we extend our early studies on the same species evaluating the chronic effect of sublethal Pb (equivalent to 5.6% of the 120-h LD-50) on free erythrocyte protoporphyrin (FEP) and blood Pb and δ-ALAD activity; blood lead was positively associated with a significant decrease in the enzyme activity and to an increase in the FEP level. Pb concentration in target organs (liver, spleen, femur, and kidney) and the total cumulated amount as well as its impact over the mass of those organs were also determined. In addition, the magnitude of the possible depuration through urine and intestine was evaluated. Our results showed that FEP, δ-ALAD, and blood Pb are reliable biosensors of chronic metal intoxication, the former being the marker with the highest sensitivity.
Starting Page	224
Ending Page	230
Page Count	7
File Format	PDF
ISSN	00904341
Journal	Archives of Environmental Contamination and Toxicology
Volume Number	46
Issue Number	2
e-ISSN	14320703
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Medicine Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers

Effect of Subacute Exposure to Lead on Responses to Estrogen in the Immature Rat Uterus

Effect of Subacute Exposure to Lead and Estrogen on Immature Pre-Weaning Rat Leukocytes

Lead Exposure at a Covered Outdoor Firing Range

Chemotaxis of Mouse Peritoneal Macrophages Following Exposure to Lead

Effects of dietary lead exposure on vitamin levels in great tit nestlings - An experimental manipulation.

Larval Growth in Postlarvae of Penaeus indicus on Exposure to Lead

Urinary Excretion of Total and Inorganic Lead in Tetraethyllead Exposed Workers

Elevated Lead Exposure in American Woodcock (Scolopax minor) in Eastern Canada

Biosensors of Inorganic Lead Exposure and Effect in an Adult Amphibian

Similar Documents

Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers

Effect of Subacute Exposure to Lead on Responses to Estrogen in the Immature Rat Uterus

Effect of Subacute Exposure to Lead and Estrogen on Immature Pre-Weaning Rat Leukocytes

Lead Exposure at a Covered Outdoor Firing Range

Chemotaxis of Mouse Peritoneal Macrophages Following Exposure to Lead

Effects of dietary lead exposure on vitamin levels in great tit nestlings - An experimental manipulation.

Larval Growth in Postlarvae of Penaeus indicus on Exposure to Lead

Urinary Excretion of Total and Inorganic Lead in Tetraethyllead Exposed Workers

Elevated Lead Exposure in American Woodcock (Scolopax minor) in Eastern Canada

Biosensors of Inorganic Lead Exposure and Effect in an Adult Amphibian