NDLI: Evolution of Dopamine-Related Systems: Biosynthesis, Degradation and Receptors

Content Provider	Springer Nature Link
Author	Ma, Xianghui Wang, Zhiwen Zhang, Xinbo
Copyright Year	2010
Abstract	The evolution of enzyme genes at the pathway level has attracted increasing attention in recent years. Most investigations have focused on microorganisms, plants and invertebrates but rarely on vertebrates. The dopamine pathway, which participates in almost every aspect of brain function, is an excellent candidate for study at the pathway level. Herein, we report data on the divergence of six dopamine metabolic enzyme genes (three anabolic, three catabolic enzymes) and five dopamine receptor genes across five mammals, namely Homo sapiens, Pan troglodytes, Macaca mulatta, Mus musculus, and Rattus norvegicus. For enzyme genes, our data confirm previous conclusion that the upstream genes have evolved more slowly than downstream genes. Moreover, we found that catabolic genes in the dopamine metabolic pathway have evolved faster than anabolic genes, and maximum likelihood analysis suggested that this difference in evolutionary rate may be explained by anabolic genes being more constrained during selection. For dopamine receptor genes, however, the broadly expressed genes have tended to evolve more slowly than the narrowly expressed genes; maximum likelihood analysis showed that the relatively rapid evolutionary rate of the narrowly expressed receptor genes was a consequence of relaxed selective constraints. Finally, our data imply that selective constraints on synonymous sites in enzyme genes are relaxed compared with those of receptor genes because of differences in their patterns of functional regulation.
Starting Page	374
Ending Page	384
Page Count	11
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	71
Issue Number	5-6
e-ISSN	14321432
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-10-02
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Molecular evolution Dopamine Anabolic pathway Catabolic pathway Receptor Nonsynonymous substitution Synonymous substitution Codon usage bias Animal Genetics and Genomics Plant Genetics & Genomics Plant Sciences Microbiology Evolutionary Biology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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