NDLI: Evaluation of Models of the Mechanisms Underlying Intron Loss and Gain in Aspergillus Fungi

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Evaluation of Models of the Mechanisms Underlying Intron Loss and Gain in Aspergillus Fungi

Content Provider	Springer Nature Link
Author	Zhang, Lei Ying Yang, Yu Fei Niu, Deng Ke
Copyright Year	2010
Abstract	Although intron loss and gain have been widely observed, their mechanisms are still to be determined. In four Aspergillus genomes, we found 204 cases of intron loss and 84 cases of intron gain. Using this data, we tested common hypotheses of intron loss or gain. Statistical analysis showed that adjacent introns tend to be lost simultaneously and small introns were preferentially lost, supporting the model of mRNA-mediated intron loss. The lost introns reside in internal regions of genes, which is inconsistent with the traditional version of the model (partial length cDNAs are reverse transcribed from 3′ ends of mRNAs), but consistent with an alternate version (partial length cDNAs are produced by self-primed reverse transcription). The latter version was not supported by examination of the abundance of T-rich segments in mRNAs. Preferential loss of internal introns might be explained by highly efficient recombination at internal regions of genes. Among the 84 cases of intron gain, we found a significantly higher frequency of short direct repeats near exon–intron boundary than in conserved introns, supporting the double-strand break repair model. We also found possible source sequences for two cases of intron gain, one by gene conversion and one by insertion of a mitochondrial sequence during double-strand break repair. Source sequences for most gained introns could not be identified and the possible reasons were discussed. In the four Aspergillus genomes studied, we did not find evidence of frequent parallel intron gains.
Starting Page	364
Ending Page	373
Page Count	10
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	71
Issue Number	5-6
e-ISSN	14321432
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-09-23
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aspergillus mRNA-mediated intron loss Parallel intron gain Orthologous genes Double-strand break repair Self-primed reverse transcription Animal Genetics and Genomics Plant Genetics & Genomics Plant Sciences Microbiology Evolutionary Biology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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