NDLI: Thermodynamic Prediction of Glycine Polymerization as a Function of Temperature and pH Consistent with Experimentally Obtained Results

Content Provider	Springer Nature Link
Author	Kitadai, rio
Copyright Year	2014
Abstract	Prediction of the thermodynamic behaviors of biomolecules at high temperature and pressure is fundamental to understanding the role of hydrothermal systems in the origin and evolution of life on the primitive Earth. However, available thermodynamic dataset for amino acids, essential components for life, cannot represent experimentally observed polymerization behaviors of amino acids accurately under hydrothermal conditions. This report presents the thermodynamic data and the revised HKF parameters for the simplest amino acid “Gly” and its polymers (GlyGly, GlyGlyGly and DKP) based on experimental thermodynamic data from the literature. Values for the ionization states of Gly (Gly+ and Gly−) and Gly peptides (GlyGly+, GlyGly−, GlyGlyGly+, and GlyGlyGly−) were also retrieved from reported experimental data by combining group additivity algorithms. The obtained dataset enables prediction of the polymerization behavior of Gly as a function of temperature and pH, consistent with experimentally obtained results in the literature. The revised thermodynamic data for zwitterionic Gly, GlyGly, and DKP were also used to estimate the energetics of amino acid polymerization into proteins. Results show that the Gibbs energy necessary to synthesize a mole of peptide bond is more than 10 kJ mol−1 less than previously estimated over widely various temperatures (e.g., 28.3 kJ mol−1 → 17.1 kJ mol−1 at 25 °C and 1 bar). Protein synthesis under abiotic conditions might therefore be more feasible than earlier studies have shown.
Starting Page	171
Ending Page	187
Page Count	17
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	78
Issue Number	3-4
e-ISSN	14321432
Language	English
Publisher	Springer US
Publisher Date	2014-03-21
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Abiotic organic synthesis Origin of life Prebiotic evolution Evolutionary Biology Microbiology Plant Sciences Plant Genetics & Genomics Animal Genetics and Genomics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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