NDLI: Significance of Mineral Salts in Prebiotic RNA Synthesis Catalyzed by Montmorillonite

Content Provider	Springer Nature Link
Author	Joshi, Prakash C. Aldersley, Michael F.
Copyright Year	2013
Abstract	The montmorillonite-catalyzed reactions of the 5′-phosphorimidazolide of adenosine used as a model generated RNA type oligomers. These reactions were found to be dependent on the presence of mineral salts. Whereas montmorillonite (pH 7) produced only dimers and traces of trimer in water, addition of sodium chloride (0.1–2.0 M) enhanced the chain length of oligomers to 10-mers as detected by HPLC. Maximum catalytic activity was observed with sodium chloride at a concentration between 0.8 and 1.2 M. This concentration of sodium chloride resembled its abundance in the ancient oceans (0.9–1.2 M). Magnesium chloride produced a similar effect but its joint action with sodium chloride did not produce any difference in the oligomer chain length. Therefore, Mg2+ was not deemed necessary for generating longer oligomers. The effect of monovalent cations upon RNA chain length was: Li+ > Na+ > K+. A similar effect was observed with the anions with enhanced oligomer length in the following order: Cl− > Br− > I−. Thus, the smaller ions facilitated the formation of the longest oligomers. Inorganic salts that tend to salt out organic compounds from water and salts which show salt-in effects had no influence on the oligomerization process indicating that the montmorillonite-catalyzed RNA synthesis is not affected by either of these hydrophobic or hydrophilic interactions. A 2.3-fold decrease in the yield of cyclic dimer was observed upon increasing the sodium chloride concentration from 0.2 to 2.0 M. Inhibition of cyclic dimer formation is vital for increasing the yield of linear dimers and longer oligomers. In summary, sodium chloride is likely to have played an essential role in any clay mineral-catalyzed prebiotic RNA synthesis.
Starting Page	371
Ending Page	379
Page Count	9
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	76
Issue Number	6
e-ISSN	14321432
Language	English
Publisher	Springer US
Publisher Date	2013-06-18
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	RNA synthesis Na+-montmorillonite Salt effect Prebiotic chemistry Evolutionary Biology Microbiology Plant Sciences Plant Genetics & Genomics Animal Genetics and Genomics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Role of Fluoride in Montmorillonite-Catalyzed RNA Synthesis

Salt-Promoted Synthesis of RNA-like Molecules in Simulated Hydrothermal Conditions

The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism

Conversion of Biosynthetic Precursors of RNA to Those of DNA by Photoredox Chemistry

Prebiotic RNA Synthesis by Montmorillonite Catalysis

Generation of Oligonucleotides Under Hydrothermal Conditions by Non-enzymatic Polymerization

Prebiotic Phosphate Ester Syntheses in a Deep Eutectic Solvent

Effect of Co-solutes on Template-Directed Nonenzymatic Replication of Nucleic Acids

The Origin of Life: Chemical Evolution of a Metabolic System in a Mineral Honeycomb?

Significance of Mineral Salts in Prebiotic RNA Synthesis Catalyzed by Montmorillonite

Similar Documents

The Role of Fluoride in Montmorillonite-Catalyzed RNA Synthesis

Salt-Promoted Synthesis of RNA-like Molecules in Simulated Hydrothermal Conditions

The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism

Conversion of Biosynthetic Precursors of RNA to Those of DNA by Photoredox Chemistry

Prebiotic RNA Synthesis by Montmorillonite Catalysis

Generation of Oligonucleotides Under Hydrothermal Conditions by Non-enzymatic Polymerization

Prebiotic Phosphate Ester Syntheses in a Deep Eutectic Solvent

Effect of Co-solutes on Template-Directed Nonenzymatic Replication of Nucleic Acids

The Origin of Life: Chemical Evolution of a Metabolic System in a Mineral Honeycomb?

Significance of Mineral Salts in Prebiotic RNA Synthesis Catalyzed by Montmorillonite