NDLI: Analysis of distribution and pharmacokinetics of litchi pericarp procyanidins in rat plasma and organs by using liquid chromatography

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Analysis of distribution and pharmacokinetics of litchi pericarp procyanidins in rat plasma and organs by using liquid chromatography–tandem mass spectrometry

European Food Research and Technology : Volume 242

European Food Research and Technology : Volume 224

Analysis of distribution and pharmacokinetics of litchi pericarp procyanidins in rat plasma and organs by using liquid chromatography–tandem mass spectrometry

Content Provider	Springer Nature Link
Author	Wu, Qian Li, Shuyi Xiao, Juan Sui, Yong Xie, Bijun Sun, Zhida
Copyright Year	2016
Abstract	Litchi pericarp procyanidins (LPP), which were mainly A-types, inhibit cardiovascular disease in vivo significantly. In order to know the pharmacokinetics of LPP, procyanidin (PC) metabolites were examined in various organs of rats at different time points after LPP ingestion. Plasma, liver, kidneys, spleen, brain, together with gastrointestinal (GI) tract of rats were collected over a 24-h period. The PC metabolic product residuals were extracted and identified by HPLC-Trap-MS–MS and LC/Q-trap-MS analyses. According to the data, there were eight PC metabolites with glucuronide, sulfate, and methyl ethers detected, in which brain was the first target of (−)-epicatechin, A-type dimers, and trimer, reaching their maximum values at 0.5 h post-administration. Liver was the major organ for glucuronidated, sulfated, and methylated transform during PC metabolism. GI tract was the primary system to recover PCs. Furthermore, all the litchi pericarp flavan-3-ols and PCs were eliminated from the stomach and GI tract 24 h after administration. (−)-Epicatechin conjugates, which were detected in plasma and brain as the major PC metabolites, demonstrating that flavan-3-ols and their metabolic products can cross the blood–brain barrier. And the results were also considerably helpful for us to know that A-type PCs are bioavailable in body.
Starting Page	167
Ending Page	176
Page Count	10
File Format	PDF
ISSN	14382377
Journal	European Food Research and Technology
Volume Number	243
Issue Number	1
e-ISSN	14382385
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-06-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Litchi pericarp Procyanidins Distribution Pharmacokinetics HPLC–MS–MS Food Science Analytical Chemistry Biotechnology Agriculture Forestry
Content Type	Text
Resource Type	Article
Subject	Industrial and Manufacturing Engineering Chemistry Biochemistry Food Science Biotechnology

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