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Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions

Psychopharmacology : Volume 233, Issue 12, June 2016

Psychopharmacology : Volume 232

Psychopharmacology : Volume 190

Psychopharmacology : Volume 168

Psychopharmacology : Volume 153

Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions

Content Provider	Springer Nature Link
Author	Seo, Mi Kyoung McIntyre, Roger S. Cho, Hye Yeon Lee, Chan Hong Park, Sung Woo Mansur, Rodrigo B. Kim, Gyung Mee Baek, Jun Hyung Woo, Young Sup Lee, Jung Goo Kim, Young Hoon
Copyright Year	2016
Abstract	Recent studies have demonstrated that mTORC1 activation may be related to antidepressant action. However, the relationship between mTORC1 signaling activation and currently prescribed antidepressants remains unclear.The aim of the present study was to determine whether alterations in mTORC1 signaling are observable following treatment with tianeptine under toxic conditions induced by B27 deprivation. Additionally, we investigated whether this drug affects synaptic proteins, neurite outgrowth, and spine density via mTORC1 signaling.Using Western blotting, we measured the phosphorylation levels of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK in rat primary hippocampal neurons. Changes in BDNF, dendritic outgrowth, spine density, and synaptic proteins (PSD-95, synaptophysin, and GluR1) were measured.Tianeptine significantly increased the phosphorylation of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK. The increase in mTOR phosphorylation was blocked by the PI3K, MEK, and mTORC1 inhibitors. Tianeptine increased BDNF, dendritic outgrowth, spine density, and synaptic proteins; all of these effects were blocked by the mTORC1 inhibitor.In this study, we demonstrated that tianeptine activates the mTORC1 signaling pathway and increases dendritic outgrowth, spine density, and synaptic proteins through mTORC1 signaling under toxic conditions in rat primary hippocampal neurons.
Starting Page	2617
Ending Page	2627
Page Count	11
File Format	PDF
ISSN	00333158
Journal	Psychopharmacology
Volume Number	233
Issue Number	13
e-ISSN	14322072
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-04-30
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antidepressant drugs Tianeptine mTORC1 signaling Neuroplasticity Toxic conditions Neurosciences Pharmacology/Toxicology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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