NDLI: Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse

Please wait, while we are loading the content...

Psychopharmacology : Volume 233, Issue 23-24, December 2016

Psychopharmacology : Volume 233, Issue 21-22, October 2016

Psychopharmacology : Volume 233, Issue 19-20, October 2016

Psychopharmacology : Volume 233, Issue 18, September 2016

Association between major depression and cardiovascular risk: the role of antidepressant medication

Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments

Male-specific effects of lipopolysaccharide on glucocorticoid receptor nuclear translocation in the prefrontal cortex of depressive rats

Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure

On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly

Effect of combined oral doses of Δ9-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea in rat models

The latent structure of impulsivity: impulsive choice, impulsive action, and impulsive personality traits

A population approach to characterise amisulpride pharmacokinetics in older people and Alzheimer’s disease

Improvement of attention with amphetamine in low- and high-performing rats

Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking

Selective attention to emotional cues and emotion recognition in healthy subjects: the role of mineralocorticoid receptor stimulation

Enhancing effect of menthol on nicotine self-administration in rats

Effects of typhoid vaccine on inflammation and sleep in healthy participants: a double-blind, placebo-controlled, crossover study

N-acetylcysteine amide (AD4) reduces cocaine-induced reinstatement

Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse

On-the-road driving performance after use of the antihistamines mequitazine and l-mequitazine, alone and with alcohol

Erratum to: The continuous performance test (rCPT) for mice: a novel operant touchscreen test of attentional function

Psychopharmacology : Volume 233, Issue 17, September 2016

Psychopharmacology : Volume 233, Issue 15-16, August 2016

Psychopharmacology : Volume 233, Issue 14, July 2016

Psychopharmacology : Volume 233, Issue 13, July 2016

Psychopharmacology : Volume 233, Issue 12, June 2016

Psychopharmacology : Volume 232

Psychopharmacology : Volume 190

Psychopharmacology : Volume 168

Psychopharmacology : Volume 153

Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse

Content Provider	Springer Nature Link
Author	Vengeliene, Valentina Cannella, Nazzare Takahashi, Tatiane Spanagel, Rainer
Copyright Year	2016
Abstract	The glutamatergic system plays a key role in the maintenance of drug use and development of drug-related conditioned behaviours. In particular, hyper-glutamatergic activity and N-methyl-D-aspartate receptor (NMDAR) activation may drive drug craving and relapse. Inhibition of kynurenine-3-monooxygenase (KMO) shifts the metabolic kynurenine pathway towards production of kynurenic acid, which leads to a reduction of glutamatergic/NMDAR activity via different mechanisms.In this study, we investigated whether drug-seeking and relapse behaviour could be modified by the metabolic shift of endogenous kynurenine pathway.An inhibitor of kynurenine-3-monooxygenase (KMO) Ro61-8048 (4 and 40 mg/kg) and its prodrug JM6 (100 and 200 mg/kg) were tested in two behavioural rat models for drug seeking and relapse—the alcohol deprivation effect (ADE) model in long-term alcohol-drinking rats and the model of cue-induced reinstatement of alcohol- and cocaine-seeking behaviour.Our results show that relapse-like alcohol drinking during the ADE was abolished by repeated intraperitoneal administration of Ro61-8048 and significantly reduced by its oral prodrug JM6. Cue-induced reinstatement of both alcohol- and cocaine-seeking behaviour was also abolished by administration of Ro61-8048.Pharmacological enhancement of endogenous kynurenic acid levels provides a novel treatment strategy to interfere with glutamatergic/NMDAR activity as well as with craving and relapse in alcohol-dependent patients and drug addicts.
Starting Page	3449
Ending Page	3459
Page Count	11
File Format	PDF
ISSN	00333158
Journal	Psychopharmacology
Volume Number	233
Issue Number	18
e-ISSN	14322072
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-07-30
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Kynurenine-3-monooxygenase Kynurenic acid Ethanol Cocaine Craving Relapse Neurosciences Pharmacology/Toxicology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV

Kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms?

Reply to: kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms?

Sex differences in reinstatement of alcohol seeking in response to cues and yohimbine in rats with and without a history of adolescent corticosterone exposure

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors

The Metabolic Factor Kynurenic Acid of Kynurenine Pathway Predicts Major Depressive Disorder

The validity of the reinstatement model of craving and relapse to drug use

Urine ethanol concentration and alcohol hangover severity

Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats

Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse

Similar Documents

Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV

Kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms?

Reply to: kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms?

Sex differences in reinstatement of alcohol seeking in response to cues and yohimbine in rats with and without a history of adolescent corticosterone exposure

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors

The Metabolic Factor Kynurenic Acid of Kynurenine Pathway Predicts Major Depressive Disorder

The validity of the reinstatement model of craving and relapse to drug use

Urine ethanol concentration and alcohol hangover severity

Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats

Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse