NDLI: Following long-term training with citalopram, both mirtazapine and mianserin block its discriminative stimulus properties in rats

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Following long-term training with citalopram, both mirtazapine and mianserin block its discriminative stimulus properties in rats

Content Provider	Springer Nature Link
Author	Dekeyne, Anne Iob, Loretta Millan, Mark J.
Copyright Year	2000
Abstract	Rationale: The discriminative stimulus (DS) properties of the selective serotonin (5-HT) uptake inhibitor (SSRI), citalopram, are mediated by 5-HT2C receptors. Interestingly, the "atypical" antidepressants, mianserin and mirtazapine, behave as antagonists at 5-HT2C receptors. Objective: Herein, we evaluated the influence of mianserin and mirtazapine upon the DS effects of citalopram. Methods: In a two-lever drug discrimination procedure, rats initially trained to discriminate citalopram (2.5 mg/kg, i.p.) from saline were retrained with a lower dose of citalopram (0.63 mg/kg, i.p.). Subsequently, generalization and antagonist studies were conducted with mianserin and mirtazapine. Results: Both dose-dependently blocked, but did not generalize to, the DS properties of citalopram without markedly disrupting response rates. Their effective dose50s were 0.1 and 1.4 mg/kg, s.c., respectively. Conclusion: These observations are consistent with a role of 5-HT2C receptors in mediation of the interoceptive properties of SSRIs and suggest that the DS effects of citalopram are not related to its "antidepressant" properties per se. Finally, they underline the distinctive nature of mirtazapine and mianserin as compared to antidepressant agents which interact with 5-HT uptake sites.
Starting Page	389
Ending Page	392
Page Count	4
File Format	PDF
ISSN	00333158
Journal	Psychopharmacology
Volume Number	153
Issue Number	3
e-ISSN	14322072
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2000-12-21
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Pharmacology/Toxicology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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