NDLI: Assessing Estrogenic Chemicals in Anchovy and Mussel Samples from Karachi, Pakistan with the Yeast Estrogen Screen Bioassay

Content Provider	Springer Nature Link
Author	Hunter, Sarah Khan, M. Z. Shieh, Ben H. H. Doerr, Barbara Ali, Sara Law, Francis C. P.
Copyright Year	2012
Abstract	Endocrine disrupting chemicals (EDCs) are introduced into the aquatic environment through industrial and municipal effluents along with urban and agricultural runoffs. Exposure of aquatic organisms to EDCs may lead to hormonal disruption and adverse health effects. The goals of our study were: to collect anchovy and mussel samples from the coastal region of Karachi, to use the yeast estrogen screen (YES) bioassay in estimating xeno-estrogen content in these samples, and to investigate if the bioassay could be used to quantify known amounts of 17β-estradiol (E2) injected into cod and salmon fillets. Results of the studies showed that mussel estrogenic activity in Karachi decreased in the order of Buleji point 1 (8.91 ± 4.77, mean ± SD) > Paradise point 1 (1.72 ± 0.81) > Paradise point 2 (0.61 ± 0.84) ng E2 equivalents/g wet wt (p < 0.05). By comparison, anchovy estrogenic activity at Korangi/Phitti Creek was much higher than at Manora. Together, these results confirmed previous reports that both Buleji point 1 and Korangi/Phitti Creek were the most contaminated areas of Karachi. The YES bioassay was only a semi-quantitative method in determining the contents of xeno-estrogens in aquatic organisms; it consistently overestimated the amounts of E2 injected into cod and salmon fillets due to additive and/or non-additive interactions between E2 and endogenous estrogens. Nevertheless, the YES bioassay was able to identify the contaminated sites in the coastal region of Karachi.
Starting Page	990
Ending Page	994
Page Count	5
File Format	PDF
ISSN	00074861
Journal	Bulletin of Environmental Contamination and Toxicology
Volume Number	89
Issue Number	5
e-ISSN	14320800
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-09-16
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Estrogenic activity Yeast estrogen screen Pakistan Aquatic species Pollution Ecotoxicology Soil Science & Conservation Environmental Chemistry Environmental Health Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Pollution Medicine Toxicology

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