NDLI: DNA-binding and hydrolytic cleavage promoted by tetraazamacycle La(III) and Ce(III) complexes

Content Provider	Springer Nature Link
Author	Jiang, Bingying Wang, Min Li, Ci Xie, Jiaqing
Copyright Year	2012
Abstract	In this work, 5,7,7,12,14,14-hexamethyl-1,4,8,11- tetraazacyclotetradecane (teta) and its two lanthanide(III) complexes, Ln(teta)(NO3)3·(Ln = La(III) and Ce(III)), have been synthesized and characterized. The interactions between pUC19 DNA and the two trivalent lanthanide complexes have been studied by UV–Vis absorption spectroscopy, fluorescence spectroscopy, and cyclic voltammetry. The results suggest that these two rare earth metal complexes can bind to plasmid DNA pUC19 non-intercalatively, and an exterior electrostatic binding is the preferred mode. And, both of these two lanthanide(III) complexes have been found to be efficient in DNA cleavage via hydrolytic pathway under very mild conditions with complex concentration of 5 × 10−3 mol L−1 at pH 7.34, 37 °C and 3 h, which that suggest these two complexes were potent agents for supercoiled pUC19 DNA cleavage hydrolytically. And, the title complexes showed efficient cleavage function on pUC19 DNA was ascribed to the special properties of trivalent lanthanide ions and the relatively small space hindrance provided by the ligand with its boat form isomer in the water medium.
Starting Page	3398
Ending Page	3404
Page Count	7
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	22
Issue Number	7
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-11-21
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tetraazamacycle lanthanide(III) complexes Interactions Exterior electrostatic binding pUC19 DNA cleavage Space hindrance Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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