NDLI: A facile route for the synthesis 1,4-disubstituted tetrazolone derivatives and evaluation of their antimicrobial activity

Content Provider	Springer Nature Link
Author	Santhoshi, Amlipur Sadhu, Partha Sarathi Sriram, Rekulapally Sai Pavan Kumar, Chebolu Naga Sesha Mahendar, Budde Sarangapani, Manda Rao, Vaidya Jayathirtha
Copyright Year	2012
Abstract	A facile route for the synthesis of 20 new 1,4-disubstituted tetrazolone derivatives from allyl bromides of Baylis–Hillman adducts and various 1-substituted tetrazolones is described. All the synthesized compounds were screened for in vitro antibacterial and antifungal activity. Out of 20 newly synthesized compounds 16 compounds showed very good activity against the Gram-positive bacteria Bacillus subtilis compare to the standard drug ciprofloxacin. The compounds 7b, 7n and 7o showed remarkable activity against both the Gram-positive bacteria B. subtilis and Staphylococcus aureus. Two compounds 7l and 7o showed very good activity against the Gram-negative bacteria Escherichia coli. The compounds, when tested for antifungal activity four compounds— 7b, 7l, 7o and 7s— showed very good activity against the strain Aspergillus niger, whereas seven compounds— 7e, 7g, 7h, 7l, 7o and 7s— display good activity against Candida albicans. Compounds 7b, 7e, 7g, 7l and 7o exhibited very good-to-high activity towards all the strains tested.
Starting Page	3329
Ending Page	3340
Page Count	12
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	22
Issue Number	7
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-11-21
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antimicrobial evaluation Baylis–Hillman bromides Drug resistant Gram-positive bacteria Gram-negative bacteria Tetrazolones Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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