NDLI: Effect on α-glucosidase inhibition and antioxidant activities of butyrolactone derivatives from Aspergillus terreus MC751

Content Provider	Springer Nature Link
Author	Dewi, Rizna Triana Tachibana, Sanro Darmawan, Ahmad
Copyright Year	2013
Abstract	Butyrolactone I and II from Aspergillus terreus MC751 as well as three synthetic butyrolactone I derivatives were assessed for α-glucosidase inhibitory and antioxidant activities. Butyrolactone I (1), which has a prenyl side chain and an alpha hydroxy-lactone group, was the most potent α-glucosidase inhibitor and also had antioxidant activities with IC50 values of 52.17 ± 5.68 and 51.39 ± 3.68 μM, respectively. In contrast, butyrolactone II (2) lacking a prenyl side chain was the most potent antioxidant with an IC50 of 17.64 ± 6.41 μM, but was less active against α-glucosidase. Acetylation of all hydroxyl groups of butyrolactone I significantly decreased both the α-glucosidase inhibitory and antioxidant activity. The prenyl and alpha hydroxy-lactone groups seem to have a synergic effect on the inhibitory activity but not antioxidant activity. This is the first structure–activity relationship report on the α-glucosidase inhibition and antioxidant activity by butyrolactone derivatives.
Starting Page	454
Ending Page	460
Page Count	7
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	23
Issue Number	1
e-ISSN	15548120
Language	English
Publisher	Springer US
Publisher Date	2013-06-05
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aspergillus terreus MC75 Butyrolactones derivatives α-Glucosidase inhibitory activity Antioxidant Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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