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Synthesis and structure–activity relationships of serotonin derivatives effect on α-glucosidase inhibition

Content Provider	Springer Nature Link
Author	Takahashi, Toshiyuki Miyazawa, Mitsuo
Copyright Year	2011
Abstract	The α-glucosidase inhibitory activities of serotonin derivatives were evaluated. Two serotonin derivatives, N-p-coumaroyl serotonin (2) and N-caffeoyl serotonin (4) exhibited most potent inhibition on α-glucosidase, whereas, cinnamic acid derivatives were less efficient. Furthermore, we analyzed their structural importance for α-glucosidase inhibition. The linkage of cinnamic acid moiety and serotonin moiety and the olefin in cinnamic acid moiety of serotonin derivatives were crucial for α-glucosidase inhibition. This is the first report on structure–activity relationships (SAR) for the α-glucosidase inhibitory activity of serotonin derivatives.
Starting Page	1762
Ending Page	1770
Page Count	9
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	21
Issue Number	8
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-06-18
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Serotonin derivatives α-Glucosidase inhibitor Diabetes Structure–activity relationship Cell Biology Pharmacology/Toxicology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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