NDLI: In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity

Content Provider	Springer Nature Link
Author	Ohlyan, Renu Kandale, Ajit Deora, Girdhar Singh Rathore, Vandana Chahal, Jagbir
Copyright Year	2012
Abstract	Indian traditional medicinal plant Piper attenuatum (Buch-Ham) has been investigated for its antioxidant and anticancer activity. Three extracts were prepared using ethyl acetate, ethanol and methanol. In vitro antioxidant activity was performed by ABTS {2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)} free radical scavenging method. All three extracts reduced the free radicals produced by ABTS in a concentration-dependent manner which could be compared to the standard (gallic acid). Invitro anticancer activity of all extracts was carried out by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay method against MCF7 (Michigan Cancer Foundation-7) cell lines. None of the extract showed anticancer activity when compared with the standard (mitomycin C) indicating that P. attenuatum is deprived of antiproliferative or cytotoxic components.
Starting Page	1365
Ending Page	1370
Page Count	6
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	22
Issue Number	3
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-06-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Piper attenuatum Anticancer MCF7 cell lines Antioxidant ABTS assay Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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