NDLI: Palladium(II) imine ligands cyclometallated complexes with a potential leishmanicidal activity on Leishmania (L.) amazonensis

Content Provider	Springer Nature Link
Author	Franco, Lilian Pereira Góis, Elba Pereira Codonho, Bárbara Santoni Pavan, Ana Laura Raymundo Oliveira Pereira, Ivan Marques, Marcos José Almeida, Eduardo Ton
Copyright Year	2012
Abstract	The leishmaniasis, considered a neglected disease, is caused by a protozoan from the genus Leishmania. There is an urgent need to search for safer, cheaper, and more effective treatments against leishmaniasis. In this context, transition metal complex activities have been studied, as palladium, which has become an interesting alternative as metal-based drugs. In this study, three new palladium(II) complexes, obtained from two imine ligands, were synthesized and characterized by elemental analyses, infrared and 1H NMR spectroscopies. The in vitro evaluation of ligands and complexes has been tested on promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and its cytotoxicity on murine macrophages. All complexes exhibited a leishmanicidal activity on promastigotes and amastigotes forms. The ligands activities were improved after coordination with palladium, and the replacement by some substituents has increased the leishmanicidal activity even more. Complexes with chloride and thiocyanate showed an improvement of activity when compared to their respective ligands, with better selectivity index (SI > 1) and less damage on mammalian cells when compared to a reference drug pentamidine. These compounds are promising agents for leishmaniasis treatment, and the results emphasize the potential properties of compounds with transition metal for medical applications.
Starting Page	1049
Ending Page	1056
Page Count	8
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	22
Issue Number	3
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-05-31
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Palladium(II) complexes Imine ligands Cyclometallated Leishmanicidal activity Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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