NDLI: Antioxidant activity and inhibition effect on the growth of human colon carcinoma (HT-29) cells of esculetin from Cortex Fraxini

Content Provider	Springer Nature Link
Author	Wang, Kai Zhang, Ye Ekunwe, S. I. N. Yi, Xianghui Liu, Xianxian Wang, Hengshan Pan, Yingming
Copyright Year	2010
Abstract	Esculetin was isolated from Cortex fraxini and identified by UV, IR, 1H NMR, 13C NMR. Its antioxidant properties were investigated employing various in vitro assays, such as 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, hydroxyl radical scavenging assay in a new resonance scattering (RS) method, reducing power and total antioxidant assay. Esculetin showed excellent antioxidant properties superior to synthetic antioxidant butylated hydroxytoluene (BHT). Subsequently, inhibition effect of esculetin on human colon carcinoma (HT-29) cells proliferation was measured by thymidine incorporation assay. HT-29 cell number was decreasing with increasing concentration of esculetin at the lower concentrations of 0.25, 0.5, 1.0, and 2.0 mg/ml, compared to the positive control and HT-29 cells were stimulated in response to treatment with esculetin which decreases in a dose-dependent manner. However, at the higher concentrations of 4.0, 8.0, 12.0 and 16.0 mg/ml, growth of HT-29 cells were inhibited in a concentration-dependent fashion.
Starting Page	968
Ending Page	974
Page Count	7
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	20
Issue Number	7
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-09-25
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Esculetin Antioxidant HT-29 cell Thymidine incorporation Cell Biology Pharmacology/Toxicology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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