NDLI: Tautomerism and multiple modelling enhance the efficacy of QSAR: antimalarial activity of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl

Content Provider	Springer Nature Link
Author	Masand, Vijay H. Mahajan, Devidas T. Gramatica, Paola Barlow, James
Copyright Year	2014
Abstract	In the present study, sixty phosphoramidate and phosphorothioamidate analogues of amiprophos methyl (APM) previously reported as potential antimalarial agents were selected to build GA-MLR QSAR models to determine the features that govern the antimalarial activity. In addition, field similarity analysis was performed to determine the molecular fields that are responsible for the difference in the activity. The two tautomeric forms, possible for the molecules in the present study, were considered to determine the effect of tautomerism on QSAR modelling. In the present analysis, a simplistic approach was employed with the assumption that all the molecules either exist in keto-type tautomeric form or in enol-type form. To get more results from QSAR analysis, multiple models were developed. All the models have been thoroughly validated according to the OECD principles. The best four-parametric GA-MLR QSAR model is with R 2 = 0.787 and $$R_{\text{ex}}^{2}$$ = 0.806 for the keto form, and R 2 = 0.785 and $$R_{\text{ex}}^{2}$$ = 0.770 for the enol form. In addition, optimum values for more easily interpretable descriptors like molecular weight (MW), lipophilicity (ALogP), etc., have been determined. The analysis reveals that consideration of tautomerism and multiple models development enhance the efficiency of QSAR analysis for lead optimization and for prediction of the activities of as-yet untested molecules.
Starting Page	4825
Ending Page	4835
Page Count	11
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	23
Issue Number	11
e-ISSN	15548120
Language	English
Publisher	Springer US
Publisher Date	2014-06-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antimalarial activity Amiprophos methyl analogues QSAR Field similarity Tautomerism Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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