NDLI: Synthesis and antimalarial activity evaluation of some isoquine analogues

Content Provider	Springer Nature Link
Author	Bora, Suranjana Chetia, Dipak Prakash, Anil
Copyright Year	2010
Abstract	The worldwide diffusion of resistance in malaria parasite, especially the Plasmodium falciparum, towards currently available drugs has become a major health and development challenges to human society. Isoquine, an isomeric analogue of amodiaquine, has been reported recently as a second generation lead compound for development of cost-effective and potentially safer alternative to amodiaquine which cause adverse effects including agranulocytosis and liver damage. In this study, a series of seven analogues of isoquine have been synthesized and subjected to in vitro antimalarial activity screening against the chloroquine sensitive 3D7 strain of Plasmodium falciparum. A simple two-step Mannich reaction was used to synthesize the compounds. All the seven compounds possessed little to moderate antimalarial activity. However, the analogues with aliphatic alcoholic amino group side chain having promising activity than the compounds with substituted aromatic ring side chain and compounds substituted with urea while analogues with heterocyclic ring side chain exhibits moderate antimalarial activity.
Starting Page	1632
Ending Page	1637
Page Count	6
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	20
Issue Number	9
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-10-12
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antimalarial Mannich reaction Isoquine Biochemistry Pharmacology/Toxicology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Aromatic amino analogues of artemisinin: synthesis and in vivo antimalarial activity

Synthesis, characterization, and antimicrobial screening of some Mannich base sydnone derivatives

Synthesis and biological evaluation of cyclopenten-1-one Mannich base oxovanadium compound

Synthesis and in vitro and in vivo antimalarial activity of novel 4-anilinoquinoline Mannich base derivatives

Synthesis, antimalarial-, and antibacterial activity evaluation of some new 4-aminoquinoline derivatives

Synthesis and evaluation of the anti-inflammatory activity of quinoline derivatives

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity

Synthesis and biological evaluation of some stilbene-based analogues

Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid

Synthesis and antimalarial activity evaluation of some isoquine analogues

Similar Documents

Aromatic amino analogues of artemisinin: synthesis and in vivo antimalarial activity

Synthesis, characterization, and antimicrobial screening of some Mannich base sydnone derivatives

Synthesis and biological evaluation of cyclopenten-1-one Mannich base oxovanadium compound

Synthesis and in vitro and in vivo antimalarial activity of novel 4-anilinoquinoline Mannich base derivatives

Synthesis, antimalarial-, and antibacterial activity evaluation of some new 4-aminoquinoline derivatives

Synthesis and evaluation of the anti-inflammatory activity of quinoline derivatives

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity

Synthesis and biological evaluation of some stilbene-based analogues

Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid

Synthesis and antimalarial activity evaluation of some isoquine analogues