NDLI: Synthesis of new N-arylamino(2-furyl)methylphosphonic acid diesters, and in vitro evaluation of their cytotoxicity against esophageal cancer cells

Content Provider	Springer Nature Link
Author	Klimczak, Anna Agnieszka Kuropatwa, Agnieszka Lewkowski, Jarosław Szemraj, Janusz
Copyright Year	2012
Abstract	N-Furfurylideneanilines and N-arylamino(2-furyl)methylphosphonates with tolyl and anisyl moieties were synthesized by the addition of phosphites to azomethine bond of corresponding Schiff bases and their NMR spectroscopic properties were investigated. Then, they were analyzed in the point of view of their influence on KYSE 30, KYSE 150, and KYSE 270 esophageal cancer cell lines and on immortalized esophageal cell line HET 1 A as a control group. Toxicity was evaluated by MTT assay. Among 11 compounds, a few of them demonstrated influence on cancer cells being neutral toward the control, but only one aminophosphonate had IC50 lower than 100 μM and acted as a potential anticancer drug. Some approaches to structure–activity relation were performed.
Starting Page	852
Ending Page	860
Page Count	9
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	22
Issue Number	2
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-05-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	N-Arylamino(2-furyl)methylphosphonate Furfural Schiff base Esophageal cancer cells Cytotoxicity Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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Synthesis of new N-arylamino(2-furyl)methylphosphonic acid diesters, and in vitro evaluation of their cytotoxicity against esophageal cancer cells