NDLI: Synthesis and antibacterial, antimycobacterial and docking studies of novel N-piperazinyl fluoroquinolones

Content Provider	Springer Nature Link
Author	Agrawal, Kapil M. Talele, Gokul S.
Copyright Year	2012
Abstract	The present study deals with the synthesis of some novel fluoroquinolone derivatives as antibacterial and antitubercular agents. The titled compounds 7a–g and 8a–g were found to possess comparable or more potent activity than the reference compounds ciprofloxacin, norfloxacin, isoniazid and rifampicin. The synthesized compounds showed activity against S. aureus and C. bacterium, whereas poor activity was observed against P. aeruginosa and E. coli. These compounds were subjected to in vitro cytotoxicity study by MTT assay, and their selectivity index was calculated. Compound 7d was found to be the most efficient antimycobacterial agent amongst the series. Molecular docking revealed that synthesized derivatives and target proteins were actively involved in a binding pattern and had significant correlation with biological activity.Novel N-piperazinyl fluoroquinolone derivatives were synthesized and evaluated for their in vitro antibacterial, antimycobacterial and cytotoxic properties. Activity results were compared with the docking results.
Starting Page	818
Ending Page	831
Page Count	14
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	22
Issue Number	2
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-05-11
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fluoroquinolone (FQ) Antibacterial Antimycobacterial Cytotoxicity Docking study Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Synthesis and antibacterial activity of novel fluoroquinolone analogs

Synthesis and antimicrobial study of fluoroquinolone-based 4-thiazolidinones

Design and synthesis of new N-substituted amino methyl-[1,2,3] triazolyl moieties of fluoroquinolones as antibacterial agents

New azetidine-3-carbonyl-N-methyl-hydrazino derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer properties

Synthesis and antibacterial activity of novel 7-haloanilino-8-nitrofluoroquinolone derivatives

Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives

Synthesis, biological activity and docking study of some new isatin Schiff base derivatives

Design, synthesis and biological activity evaluation of novel pefloxacin derivatives as potential antibacterial agents

Stereo-selective synthesis, structural and antibacterial studies of novel glycosylated β2,3-amino acid analogues

Synthesis and antibacterial, antimycobacterial and docking studies of novel N-piperazinyl fluoroquinolones

Similar Documents

Synthesis and antibacterial activity of novel fluoroquinolone analogs

Synthesis and antimicrobial study of fluoroquinolone-based 4-thiazolidinones

Design and synthesis of new N-substituted amino methyl-[1,2,3] triazolyl moieties of fluoroquinolones as antibacterial agents

New azetidine-3-carbonyl-N-methyl-hydrazino derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer properties

Synthesis and antibacterial activity of novel 7-haloanilino-8-nitrofluoroquinolone derivatives

Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives

Synthesis, biological activity and docking study of some new isatin Schiff base derivatives

Design, synthesis and biological activity evaluation of novel pefloxacin derivatives as potential antibacterial agents

Stereo-selective synthesis, structural and antibacterial studies of novel glycosylated β2,3-amino acid analogues

Synthesis and antibacterial, antimycobacterial and docking studies of novel N-piperazinyl fluoroquinolones