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| Content Provider | Springer Nature Link |
|---|---|
| Author | Muik, Martin Schindl, Rainer Fahrner, Marc Romanin, Christoph |
| Copyright Year | 2012 |
| Abstract | Store-operated Ca2+ entry describes the phenomenon that connects a depletion of internal Ca2+ stores to an activation of plasma membrane-located Ca2+ selective ion channels. Tremendous progress towards the underlying molecular mechanism came with the discovery of the two respective limiting components, STIM and Orai. STIM1 represents the ER-located Ca2+ sensor and transmits the signal of store depletion to the plasma membrane. Here it couples to and activates Orai, the highly Ca2+-selective pore-forming subunit of Ca2+ release-activated Ca2+ channels. In this review, we focus on the molecular steps that these two proteins undergo from store-depletion to their coupling, the activation, and regulation of Ca2+ currents. |
| Starting Page | 4163 |
| Ending Page | 4176 |
| Page Count | 14 |
| File Format | |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 69 |
| Issue Number | 24 |
| e-ISSN | 14209071 |
| Language | English |
| Publisher | SP Birkhäuser Verlag Basel |
| Publisher Date | 2012-07-17 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | STIM1 Orai STIM1/Orai interaction Orai gating STIM1 structure Cell Biology Biomedicine general Life Sciences Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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