NDLI: Regulation of pre-T-cell development

Content Provider	Springer Nature Link
Author	Möröy, T. Karsunky, H.
Copyright Year	2000
Abstract	One important pillar of cellular immune defense in mammals is the T-lymphoid compartment which produces cells that are able to specifically recognize foreign peptide antigens through a membrane-bound receptor. These T-cells can trigger a variety of defense mechanisms upon antigen stimulation ranging from the production of potent cytokines to the direct killing of virus-infected cells. The production of such highly specialized T-cells takes place in the thymus and requires a stringent process of differentiation and selection of precursor cells that are delivered from the bone marrow. In the thymus, several waves of proliferative expansion and selection ensure the production of a large repertoire of antigen-specific T-cells that each bear a unique T-cell receptor (TCR) which is able to recognize foreign antigens but can tolerate the own host-specific peptide structures. Education of precursors to mature T-cells in the thymus requires a dense network of regulatory processes acting at receptor-ligand interactions, signal transduction, genomic rearrangement of TCR gene loci, cell cycle progression, transcriptional control and programmed cell death.
Starting Page	957
Ending Page	975
Page Count	19
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	57
Issue Number	6
e-ISSN	14209071
Language	English
Publisher	Birkhäuser Verlag
Publisher Date	2000-06-01
Publisher Place	Basel
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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