NDLI: Regulation of osteoclasts by membrane-derived lipid mediators

Content Provider	Springer Nature Link
Author	Oikawa, Tsukasa Kuroda, Yukiko Matsuo, Koichi
Copyright Year	2013
Abstract	Osteoclasts are bone-resorbing cells of monocytic origin. An imbalance between bone formation and resorption can lead to osteoporosis or osteopetrosis. Osteoclastogenesis is triggered by RANKL- and IP3-induced Ca2+ influx followed by activation of NFATc1, a master transcription factor for osteoclastogenic gene regulation. During differentiation, osteoclasts undergo cytoskeletal remodeling to migrate and attach to the bone surface. Simultaneously, they fuse with each other to form multinucleated cells. These processes require PI3-kinase-dependent cytoskeletal protein activation to initiate cytoskeletal remodeling, resulting in the formation of circumferential podosomes and fusion-competent protrusions. In multinucleated osteoclasts, circumferential podosomes mature into stabilized actin rings, which enables the formation of a ruffled border where intensive membrane trafficking is executed. Membrane lipids, especially phosphoinositides, are key signaling molecules that regulate osteoclast morphology and act as second messengers and docking sites for multiple important effectors. We examine the critical roles of phosphoinositides in the signaling cascades that regulate osteoclast functions.
Starting Page	3341
Ending Page	3353
Page Count	13
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	70
Issue Number	18
e-ISSN	14209071
Language	English
Publisher	Springer Basel
Publisher Date	2013-01-08
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	IP3 PI3-kinase Circumferential podosome Fusion-competent protrusion Actin ring Ruffled border Cell Biology Biomedicine general Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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