NDLI: Cell death proteins as markers of early postmortem interval

Content Provider	Springer Nature Link
Author	C. Zapico, Sara Menéndez, Sofía T. Núñez, Paula
Copyright Year	2013
Abstract	Estimation of time since death is one of the challenges in forensic science. There are many approaches to estimate the postmortem interval, including both physical and thanatochemistry methods. Decomposition is triggered by a process called autolysis, which induces destructive changes in the cell leading to cell death. Based on the process of cell death signaling, this study analyzed the early postmortem interval (2–8 h since death) using the study of the mRNA expression of Fas Ligand (FasL) and phosphatase and tensin homologue deleted on chromosome 10 (PTEN) by Quantitative-PCR. Results of the study indicate a time-dependent increase in the mRNA levels of both proteins up until 6 h after death. Using a regression analysis in these first 6 h, a positive linear correlation was found between the mRNA expression of these proteins and the time since death. Since PTEN and FasL are implicated in signaling pathways, both proteins are potential candidates to analyze the time since death in time intervals of 6 h or less. Further research is needed to find additional cell death markers and expand the time period for time since death estimation.
Starting Page	2957
Ending Page	2962
Page Count	6
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	71
Issue Number	15
e-ISSN	14209071
Language	English
Publisher	Springer Basel
Publisher Date	2013-12-03
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Postmortem interval Cell death markers mRNA PTEN FasL Cell Biology Biomedicine general Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

G proteins as drug targets

Diverse molecular functions of Hu proteins

Control of death receptor ligand activity by posttranslational modifications

Decoding the iceman’s death?

Genetic alterations of PTEN in human melanoma

Early days of Structural Biology

Resistant penicillin-binding proteins

Emerging functions of matricellular proteins

Death Effector Domain-Containing Proteins

Cell death proteins as markers of early postmortem interval

Similar Documents

G proteins as drug targets

Diverse molecular functions of Hu proteins

Control of death receptor ligand activity by posttranslational modifications

Decoding the iceman’s death?

Genetic alterations of PTEN in human melanoma

Early days of Structural Biology

Resistant penicillin-binding proteins

Emerging functions of matricellular proteins

Death Effector Domain-Containing Proteins

Cell death proteins as markers of early postmortem interval