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  1. Cellular and Molecular Life Sciences
  2. Cellular and Molecular Life Sciences : Volume 67
  3. Cellular and Molecular Life Sciences : Volume 67, Issue 1, January 2010
  4. When a theory of aging ages badly
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Cellular and Molecular Life Sciences : Volume 73
Cellular and Molecular Life Sciences : Volume 72
Cellular and Molecular Life Sciences : Volume 71
Cellular and Molecular Life Sciences : Volume 70
Cellular and Molecular Life Sciences : Volume 69
Cellular and Molecular Life Sciences : Volume 68
Cellular and Molecular Life Sciences : Volume 67
Cellular and Molecular Life Sciences : Volume 67, Issue 24, December 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 23, December 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 21, November 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 22, November 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 20, October 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 19, October 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 17, September 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 18, September 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 15, August 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 16, August 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 13, July 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 14, July 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 12, June 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 11, June 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 10, May 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 9, May 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 7, April 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 8, April 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 5, March 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 6, March 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 4, February 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 3, February 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 2, January 2010
Cellular and Molecular Life Sciences : Volume 67, Issue 1, January 2010
When a theory of aging ages badly
Cyclotides: macrocyclic peptides with applications in drug design and agriculture
The M-superfamily of conotoxins: a review
Localization of Golgi-resident glycosyltransferases
Non-B DNA structure-induced genetic instability and evolution
The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells
Neuroscience of alcoholism: molecular and cellular mechanisms
Not just angiotensinases: new roles for the angiotensin-converting enzymes
Melanopsin and inner retinal photoreception
Spermine synthase
Role of hepcidin in murine brain iron metabolism
Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis
Dependence of 6β-acetoxy-7α-hydroxyroyleanone block of Kv1.2 channels on C-type inactivation
Regulation of HERG (KCNH2) potassium channel surface expression by diacylglycerol
Cellular and Molecular Life Sciences : Volume 66
Cellular and Molecular Life Sciences : Volume 65
Cellular and Molecular Life Sciences : Volume 64
Cellular and Molecular Life Sciences : Volume 63
Cellular and Molecular Life Sciences : Volume 62
Cellular and Molecular Life Sciences : Volume 61
Cellular and Molecular Life Sciences : Volume 60
Cellular and Molecular Life Sciences : Volume 59
Cellular and Molecular Life Sciences : Volume 58
Cellular and Molecular Life Sciences : Volume 57
Cellular and Molecular Life Sciences : Volume 56
Cellular and Molecular Life Sciences : Volume 55
Cellular and Molecular Life Sciences : Volume 54
Cellular and Molecular Life Sciences : Volume 53

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When a theory of aging ages badly

Content Provider Springer Nature Link
Author Lapointe, Jérôme Hekimi, Siegfried
Copyright Year 2009
Abstract According to the widely acknowledged mitochondrial free radical theory of aging (MFRTA), the macromolecular damage that results from the production of toxic reactive oxygen species (ROS) during cellular respiration is the cause of aging. However, although it is clear that oxidative damage increases during aging, the fundamental question regarding whether mitochondrial oxidative stress is in any way causal to the aging process remains unresolved. An increasing number of studies on long-lived vertebrate species, mutants and transgenic animals have seriously challenged the pervasive MFRTA. Here, we describe some of these new results, including those pertaining to the phenotype of the long-lived Mclk1 +/− mice, which appear irreconcilable with the MFRTA. Thus, we believe that it is reasonable to now consider the MFRTA as refuted and that it is time to use the insight gained by many years of testing this theory to develop new views as to the physiological causes of aging.
Starting Page 1
Ending Page 8
Page Count 8
File Format PDF
ISSN 1420682X
Journal Cellular and Molecular Life Sciences
Volume Number 67
Issue Number 1
e-ISSN 14209071
Language English
Publisher SP Birkhäuser Verlag Basel
Publisher Date 2009-09-03
Publisher Place Basel
Access Restriction Subscribed
Subject Keyword Biochemistry Life Sciences Biomedicine general Cell Biology
Content Type Text
Resource Type Article
Subject Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience
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