NDLI: Role of hepcidin in murine brain iron metabolism

Content Provider	Springer Nature Link
Author	Wang, S. M. Fu, L. J. Duan, X. L. Crooks, D. R. Yu, P. Qian, Z. M. Di, X. J. Li, J. Rouault, T. A. Chang, Y. Z.
Copyright Year	2009
Abstract	Brain iron homeostasis is maintained by a balance of both iron uptake and release, and accumulating evidence has revealed that brain iron concentrations increase with aging. Hepcidin, an iron regulatory hormone produced by hepatocytes in response to inflammatory stimuli, iron, and hypoxia, has been shown to be the long-sought hormone responsible for the regulation of body iron balance and recycling in mammals. In this study, we report that hepcidin is widely expressed in the murine brain. In cerebral cortex, hippocampus and striatum, hepcidin mRNA levels increased with aging. Injection of hepcidin into the lateral cerebral ventricle resulted in decreased Fpn1 protein levels in cerebral cortex, hippocampus, and striatum. Additionally, treatment of primary cultured neurons with hepcidin caused decreased neuronal iron release and Fpn1 protein levels. Together, our data provide further evidence that hepcidin may be involved in the regulation of brain iron metabolism.
Starting Page	123
Ending Page	133
Page Count	11
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	67
Issue Number	1
e-ISSN	14209071
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2009-11-08
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Hepcidin Ferroportin1 Brain iron metabolism Aging Murine Biochemistry Life Sciences Biomedicine general Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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