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Content Provider | Springer Nature Link |
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Author | Legrand, D. Elass, E. Carpentier, M. Mazurier, J. |
Copyright Year | 2005 |
Abstract | Lactoferrin is an iron-binding glycoprotein of the transferrin family. Abundant expression and secretion of lactoferrin, in particular in milk and fluids of the digestive tract, are related to its implication in the first line of host defense. Lactoferrin is also a prominent component of the secondary granules of neutrophils (PMNs) and is released in infected tissues and blood during the inflammatory process. In addition to its direct antimicrobial properties, the abilities of lactoferrin to regulate the immune response and to protect against infection and septic shock have been described in numerous in vitro and in vivo studies. Although the cellular and molecular mechanisms that account for the modulation of the inflammatory and immune responses by lactoferrin are not yet totally elucidated, many are now established. At the cellular level, lactoferrin modulates the migration, maturation and function of immune cells. At the molecular level and in addition to iron binding, interactions of lactoferrin with a plethora of compounds, either soluble or membrane molecules, account for its modulatory properties. This paper reviews our current understanding of the cellular and molecular mechanisms that explain the regulatory properties of lactoferrin in host defence. |
Starting Page | 2549 |
Ending Page | 2559 |
Page Count | 11 |
File Format | |
ISSN | 1420682X |
Journal | Cellular and Molecular Life Sciences |
Volume Number | 62 |
Issue Number | 22 |
e-ISSN | 14209071 |
Language | English |
Publisher | Birkhäuser-Verlag |
Publisher Date | 2005-11-02 |
Publisher Place | Basel |
Access Restriction | Subscribed |
Subject Keyword | Lactoferrin inflammation immunity ROS Th1 Cell Biology Biomedicine general Life Sciences Biochemistry |
Content Type | Text |
Resource Type | Article |
Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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