NDLI: The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis

Content Provider	Springer Nature Link
Author	Kodama, S. Davis, M. Faustman, D. L.
Copyright Year	2005
Abstract	Excess levels of tumor necrosis factor-α (TNF-α) have been associated with certain autoimmune diseases. Under the rationale that elevated TNF-α levels are deleterious, several anti-TNF-α therapies are now available to block the action of TNF-α in patients with autoimmune diseases with a chronic inflammatory component to the destructive process. TNF-α antagonists have provided clinical benefit to many patients, but their use also is accompanied by new or aggravated forms of autoimmunity. Here we propose a mechanistically based hypothesis for the adverse events observed with TNF-α antagonists, and argue for the opposite therapeutic strategy: to boost or restore TNF-α activity as a treatment for some forms of autoimmunity. Activation defects in the transcription factor nuclear factor κB leave autoreactive T cells sensitive to TNF-α-induced apoptosis. Treatment with TNF-α, by destroying autoreactive T cells, appears to be a highly targeted strategy to interrupt the pathogenesis of type 1 diabetes, lupus and certain forms of autoimmunity.
Starting Page	1850
Ending Page	1862
Page Count	13
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	62
Issue Number	16
e-ISSN	14209071
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2005-06-17
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	NF-κB TNF-α apoptosis autoimmunity Life Sciences Biomedicine general Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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