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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jaworski, Maike Thome, Margot |
| Copyright Year | 2015 |
| Abstract | The paracaspase MALT1 has a central role in the activation of lymphocytes and other immune cells including myeloid cells, mast cells and NK cells. MALT1 activity is required not only for the immune response, but also for the development of natural Treg cells that keep the immune response in check. Exaggerated MALT1 activity has been associated with the development of lymphoid malignancies, and recently developed MALT1 inhibitors show promising anti-tumor effects in xenograft models of diffuse large B cell lymphoma. In this review, we provide an overview of the present understanding of MALT1’s function, and discuss possibilities for its therapeutic targeting based on recently developed inhibitors and animal models. |
| Starting Page | 459 |
| Ending Page | 473 |
| Page Count | 15 |
| File Format | |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 73 |
| Issue Number | 3 |
| e-ISSN | 14209071 |
| Language | English |
| Publisher | Springer International Publishing |
| Publisher Date | 2015-10-27 |
| Publisher Place | Cham |
| Access Restriction | Subscribed |
| Subject Keyword | NF-κB Autoimmunity Lymphoma Protease Regulatory T cells Cell Biology Biomedicine general Life Sciences Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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