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| Content Provider | Springer Nature Link |
|---|---|
| Author | Rytinki, Miia M. Lakso, Merja Pehkonen, Petri Aarnio, Vuokko Reisner, Kaja Peräkylä, Mikael Wong, Garry Palvimo, Jorma J. |
| Copyright Year | 2011 |
| Abstract | Small ubiquitin-related modifiers (SUMOs) are important regulator proteins. Caenorhabditis elegans contains a single SUMO ortholog, SMO-1, necessary for the reproduction of C. elegans. In this study, we constructed transgenic C. elegans strains expressing human SUMO-1 under the control of pan-neuronal (aex-3) or pan-muscular (myo-4) promoter and SUMO-2 under the control of myo-4 promoter. Interestingly, muscular overexpression of SUMO-1 or -2 resulted in morphological changes of the posterior part of the nematode. Movement, reproduction and aging of C. elegans were perturbed by the overexpression of SUMO-1 or -2. Genome-wide expression analyses revealed that several genes encoding components of SUMOylation pathway and ubiquitin-proteasome system were upregulated in SUMO-overexpressing nematodes. Since muscular overexpression of SMO-1 also brought up reproductive and mobility perturbations, our results imply that the phenotypes were largely due to an excess of SUMO, suggesting that a tight control of SUMO levels is important for the normal development of multicellular organisms. |
| Starting Page | 3219 |
| Ending Page | 3232 |
| Page Count | 14 |
| File Format | |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 68 |
| Issue Number | 19 |
| e-ISSN | 14209071 |
| Language | English |
| Publisher | SP Birkhäuser Verlag Basel |
| Publisher Date | 2011-01-21 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | SUMO (small ubiquitin-related modifier) Ubiquitin Cell stress Monoubiquitylated histone 2B Development Gene expression Muscle C. elegans Biochemistry Life Sciences Biomedicine general Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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