NDLI: Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell

Content Provider	Springer Nature Link
Author	Kudo, Akira
Copyright Year	2011
Abstract	More than 10 years have passed since the naming of periostin derived from its expression sites in the periosteum and periodontal ligament. Following this finding, we have accumulated more data on the expression patterns of periostin, and, finally, with the generation of periostin-deficient mice, have revealed functions of periostin in the regeneration of tissues in bone, tooth, heart, and skin, and its action in cancer invasion. Since periostin is a matricellular protein, the first investigation of periostin function showed its enhancement of cell migration by acting outside the cell. On the other hand, recent observations have demonstrated that periostin functions in fibrillogenesis in association with extracellular matrix molecules inside the cell.
Starting Page	3201
Ending Page	3207
Page Count	7
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	68
Issue Number	19
e-ISSN	14209071
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2011-08-11
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Periostin Fibrillogenesis Bone Type I collagen Tooth Heart Matricellular protein ECM Biochemistry Life Sciences Biomedicine general Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell