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| Content Provider | Springer Nature Link |
|---|---|
| Author | Schminke, Boris Muhammad, Hayat Bode, Christa Sadowski, Boguslawa Gerter, Regina Gersdorff, Nikolaus Bürgers, Ralf Monsonego Ornan, Efrat Rosen, Vicki Miosge, Nicolai |
| Copyright Year | 2013 |
| Abstract | Discoidin domain receptor 1 (DDR-1)-deficient mice exhibited a high incidence of osteoarthritis (OA) in the temporomandibular joint (TMJ) as early as 9 weeks of age. They showed typical histological signs of OA, including surface fissures, loss of proteoglycans, chondrocyte cluster formation, collagen type I upregulation, and atypical collagen fibril arrangements. Chondrocytes isolated from the TMJs of DDR-1-deficient mice maintained their osteoarthritic characteristics when placed in culture. They expressed high levels of runx-2 and collagen type I, as well as low levels of sox-9 and aggrecan. The expression of DDR-2, a key factor in OA, was increased. DDR-1-deficient chondrocytes from the TMJ were positively influenced towards chondrogenesis by a three-dimensional matrix combined with a runx-2 knockdown or stimulation with extracellular matrix components, such as nidogen-2. Therefore, the DDR-1 knock-out mouse can serve as a novel model for temporomandibular disorders, such as OA of the TMJ, and will help to develop new treatment options, particularly those involving tissue regeneration. |
| Starting Page | 1081 |
| Ending Page | 1096 |
| Page Count | 16 |
| File Format | |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 71 |
| Issue Number | 6 |
| e-ISSN | 14209071 |
| Language | English |
| Publisher | Springer Basel |
| Publisher Date | 2013-08-04 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | Temporomandibular joint Osteoarthritis Extracellular matrix Collagen receptor Chondrocyte signaling Cell Biology Biomedicine general Life Sciences Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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