NDLI: Effects of ammonium tetrathiomolybdate, an oncolytic/angiolytic drug on the viability and proliferation of endothelial and tumor cells

Content Provider	Springer Nature Link
Author	Carpenter, A. Rassam, A. Jennings, M. H. Robinson Jackson, S. Alexander, J. S. Erkuran Yilmaz, C.
Copyright Year	2007
Abstract	This study examines the target specificity of tetrathiomolybdate (ATM), an anti-angiogenic, anti-tumor agent against the viability / proliferation of arterial, venous, capillary endothelial and tumor cells.Cells were seeded at 10 or 100% density (to measure viability / proliferation respectively) in medium ± 0–250 uM ATM. Viability and proliferation were measured by metabolic labeling-colorimetry. One-way ANOVA + Bonferroni testing examined base metabolism; Dunnett’s testing was used for viability/proliferation.Venous proliferation showed high ATM sensitivity (50% reduction ~ ≥5 uM ATM, p<0.01), capillary proliferation was inhibited ≥10 uM (p<0.05). Arterial endothelium were less sensitive to ATM, (50% inhibition ~ ≥ 20 uM, p<0.01). YPEN-1 were inhibited >50 uM ATM. Capillary viability was inhibited ≥20 μM ATM (p<0.01); venous, arterial and tumor viability show less ATM sensitivity.Our data suggest that venous and capillary endothelial proliferation are important targets in ATM therapy, but that other vascular segments and tumor cells may be less influenced.
Starting Page	515
Ending Page	519
Page Count	5
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	56
Issue Number	12
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2007-12-21
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cancer Angiogenesis Anti-angiogenesis Vascularization Endothelial cells Tumor Rheumatology Neurology Dermatology Allergology Pharmacology/Toxicology Immunology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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