NDLI: Recombinant human growth hormone improves survival and protects against acute lung injury in murine Staphylococcus aureus sepsis

Content Provider	Springer Nature Link
Author	Yi, C. Cao, Y. Mao, S. H. Liu, H. Ji, L. L. Xu, S. Y. Zhang, M. Huang, Y.
Copyright Year	2009
Abstract	To investigate whether recombinant human growth hormone (rhGH) reduces mortality and protects against Staphylococcus aureus sepsis-induced acute lung injury.The bacteria-positive rate of blood smears and bacteria colony counts in bacteria plate culture, TNFα and IL-10 plasma levels, lung injury score, expression of intercellular adhesion molecule-1 (ICAM-1) as well as activation of nuclear factor-kappa B (NF-κB) in the lungs were determined 6, 12 and 24 h after 140 KM mice were injected with physiologic saline (i.p. group C, n = 20); S. aureus E311122 (1.75 × 1012 cfu/L, 40 ml/kg, i.p. group S, n = 60); or S. aureus (as group S) with a subsequent treatment of rhGH (1.0 U kg−1 day−1), i.m. group T, n = 60). The cumulative survival rate of an additional 15 mice from each group was followed for 7 days post S. aureus injection.rhGH treatment significantly increased IL-10 plasma levels and the 7-day cumulative survival rate, whereas the bacteria-positive rate of blood smears, bacteria colony counts in bacteria plate cultures, lung injury score, ICAM-1 and NF-κB expression in the lungs were significantly reduced. In addition, rhGH treatment significantly suppressed the S. aureus sepsis-induced elevation of TNFα plasma levels.These results indicate an ability of rhGH to prevent S. aureus sepsis-induced acute lung injury in mice, which may be attributed to attenuation of increased plasma TNFα levels, and elevated IL-10 plasma levels as well as reduced ICAM-1 expression and inhibited NF-κB activity in the lungs.
Starting Page	855
Ending Page	862
Page Count	8
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	58
Issue Number	12
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2009-06-18
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Sepsis Growth hormone Lung injury Intercellular adhesion molecule-1 (ICAM-1) Nuclear factor-kappa B (NF-κB) Neurology Dermatology Allergology Rheumatology Pharmacology/Toxicology Immunology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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