NDLI: Infection with murine gammaherpesvirus 68 exacerbates inflammatory bowel disease in IL-10-deficient mice

Content Provider	Springer Nature Link
Author	Nelson, D. A. Petty, C. C. Bost, Kenneth L.
Copyright Year	2009
Abstract	We questioned whether infection with murine gammaherpesvirus 68 (HV-68) might exacerbate inflammatory bowel disease using mice deficient in IL-10 (IL-10−/−) as a model of developing colitis.Groups of C57BL/6 mice and IL-10−/− mice were mock-treated or infected with HV-68. Two months following infection, mice were euthanized and a variety of parameters were measured to quantify the extent of inflammation and the presence of virus. Measurements included survival, body weight, splenomegaly, colonic disease scores, liver histopathology, viable bacteria in the liver, and splenic viral burden.IL-10−/− mice infected with HV-68 displayed reduced survival, lower body weights, increased splenomegaly, exacerbated colonic disease scores, increased numbers of viable bacteria in the liver, and increased leukocyte liver infiltration when compared to mock-treated IL-10−/− mice or HV-68 infected C57BL/6 mice. Surprisingly, levels of infectious or latent virus were not significantly different between the groups of mice exposed to HV-68.The presence of HV-68 in IL-10−/− mice exacerbates the developing clinical disease in this animal model of colitis.
Starting Page	881
Ending Page	889
Page Count	9
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	58
Issue Number	12
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2009-06-21
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	IL-10 Gammaherpesvirus Inflammatory bowel disease Colitis Neurology Dermatology Allergology Rheumatology Pharmacology/Toxicology Immunology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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