NDLI: The role of tissue mast cells in polyacrylamide gel-induced inflammation in mice

Content Provider	Springer Nature Link
Author	Harris, R. R. Wilcox, D. Bell, R. L. Carter, G. W.
Copyright Year	1998
Abstract	Objective and Design: In the present study, we investigated the role of mast cells in a model of polyacrylamide gel (PAG)-induced inflammation in mice.¶Subjects: Balb/c mice and two strains of mast cell deficient mice (WBB6F1/J-W/Wv, WCB6F1/J-S1/S1d).¶Treatment: Various quantities of polyacrylamide gel (Bio-Gel P4) were injected subcutaneously in the backs of mice.¶Methods: Five hours after the injection of PAG the animals were euthanized, the injection sites lavaged and levels of LTB4, PGE2, TNFα and cells were determined.¶Results: Subcutaneous injection of PAG caused a time-dependent response characterized by the accumulation of inflammatory cells peaking at 10 h and the formation of LTB4, PGE2 and TNFα, peaking at 5 h. PAG injection into W/Wv or SL/SLd mice (mice lacking mast cells) resulted in an attenuated response, i.e. LTB4 levels were reduced by 60% and minimal cell influx was seen. The lack of mast cells caused about a 30% reduction in the levels of TNFα found.¶Conclusions: These data suggest that mast cells play a prominent role in the PMN influx, TNFα production and eicosanoid formation in the PAG-induced inflammatory response.
Starting Page	104
Ending Page	108
Page Count	5
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	47
Issue Number	3
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2004-02-19
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Pharmacology/Toxicology Rheumatology Allergology Dermatology Neurology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mast cells and eosinophils: the two key effector cells in allergic inflammation

Increases in mast cells and chymase in fibroproliferative paws of collagen-induced arthritic mice

Adenosine, mast cells and asthma

The role of mast cells in ischemia and reperfusion injury

Advanced Approaches to Mast Cells & Basophils

Tumor bearing decreases systemic acute inflammation in rats – role of mast cell degranulation

Antagonism between histamine and polyamines in mast cells

Symposium 4: The Role of Cytokines in Inflammation

Neutrophil recruitment in mast cell-dependent inflammation: inhibitory mechanisms of glucocorticoids

The role of tissue mast cells in polyacrylamide gel-induced inflammation in mice

Similar Documents

Mast cells and eosinophils: the two key effector cells in allergic inflammation

Increases in mast cells and chymase in fibroproliferative paws of collagen-induced arthritic mice

Adenosine, mast cells and asthma

The role of mast cells in ischemia and reperfusion injury

Advanced Approaches to Mast Cells & Basophils

Tumor bearing decreases systemic acute inflammation in rats – role of mast cell degranulation

Antagonism between histamine and polyamines in mast cells

Symposium 4: The Role of Cytokines in Inflammation

Neutrophil recruitment in mast cell-dependent inflammation: inhibitory mechanisms of glucocorticoids

The role of tissue mast cells in polyacrylamide gel-induced inflammation in mice