NDLI: Carrageenan-induced transient inflammation in a rabbit knee model: molecular changes consistent with an early osteoarthritis phenotype

Content Provider	Springer Nature Link
Author	Achari, Yamini Re, Carol R. Frank, Cyril B. Hart, David A.
Copyright Year	2012
Abstract	Inflammation following a knee injury is one of the factors associated with initiation of cartilage degeneration leading to osteoarthritis (OA). The hypothesis tested was that inflammation results in elevated expression of proteinases implicated in OA.Mature female rabbits received a single carrageenan injection to the right hind knee and the left knee served as the control. Five animals were killed at time points of 1, 2 and 4 weeks. The synovium and cartilage from both knees were collected and analysed for specific mRNA levels.Interleukin (IL)-1β and IL-6 mRNA levels peaked at 2 weeks and returned to normal levels in tissues by 4 weeks post-carrageenan treatment. Matrix metalloproteinase (MMP)-13, MMP-1, MMP-3 and cathepsin K followed the trend set by the inflammatory cytokines. Both synovium and cartilage tissues exhibited similar patterns of molecular expression, with cartilage from the tibial plateau responding more strongly than the femoral condyles.The acute inflammatory milieu controls the transient expression of many degradative proteinases in the knee. However, a single acute exposure to inflammation in the rabbit knee is insufficient to create a chronic inflammatory environment and other complementary factors, such as persistent mechanical instability and/or injury, may contribute to the establishment of OA.
Starting Page	907
Ending Page	914
Page Count	8
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	61
Issue Number	8
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2012-05-13
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Carrageenan Cartilage Knee joints Anterior cruciate ligament Immunology Pharmacology/Toxicology Neurology Rheumatology Dermatology Allergology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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