NDLI: Association of promoter region single nucleotide polymorphisms at positions −819C/T and −592C/A of interleukin 10 gene with ischemic heart disease

Content Provider	Springer Nature Link
Author	Yu, Gyeong Im Cho, Ho Chan Cho, Yun Kyeong Park, Hyoung Seob Yoon, Hyuck Jun Kim, Hyung Seop Nam, Chang Wook Kim, Yoon Nyun Kim, Kwon Bae Ha, Eunyoung Shin, Dong Hoon Hur, Seung Ho
Copyright Year	2012
Abstract	Ischemic heart disease (IHD) is a disease characterized by ischemia of the heart muscle, usually due to coronary artery disease. Interleukin-10 (IL10) is a proinflammatory cytokine known to protect endothelial function. In this study, we investigated the association of promoter region polymorphisms of the IL10 gene with IHD.We recruited 313 control and 173 IHD patients. The selected SNPs in IL10 were genotyped using pyrosequencing.SNPs at positions −592C/A and −819C/T were statistically associated with IHD (P = 0.014 and P = 0.037). Similarly, the mean value of C-reactive protein in the C allele at −592C/A and −819C/T was significantly higher than that in the A allele at −592C/A (P = 0.026) and T allele at −819C/T (P = 0.026). The presence of hypertension in the C allele at −592C/A and −819C/T was significantly more frequent than that in the A allele at −592C/A (P = 0.044) and T allele at −819C/T (P = 0.044). In the haplotype of two SNPs (−592C/A and −819C/T), one haplotype (CC) presented an association with IHD (P = 0.012).These results indicate that the C allele with SNPs at position −592C/A and −819C/T of IL10 gene may be associated with IHD in the Korean population.
Starting Page	899
Ending Page	905
Page Count	7
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	61
Issue Number	8
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2012-05-17
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ischemic heart disease Interleukin-10 Single nucleotide polymorphism Immunology Pharmacology/Toxicology Neurology Rheumatology Dermatology Allergology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Interleukin 10 promoter region polymorphisms in inflammatory bowel disease in Tunisian population

Association of interleukin-10 gene promoter polymorphism in spontaneous abortions: a family-based triad study

Association of interleukin-1 gene polymorphisms with multiple sclerosis: a meta-analysis

Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: a meta-analysis

Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis

The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis

Promoter –2518 single nucleotide polymorphism of monocyte chemoattractant protein-1 is associated with clinical severity in Behçet’s disease

Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population

TLR4 polymorphisms and disease susceptibility

Association of promoter region single nucleotide polymorphisms at positions −819C/T and −592C/A of interleukin 10 gene with ischemic heart disease

Similar Documents

Interleukin 10 promoter region polymorphisms in inflammatory bowel disease in Tunisian population

Association of interleukin-10 gene promoter polymorphism in spontaneous abortions: a family-based triad study

Association of interleukin-1 gene polymorphisms with multiple sclerosis: a meta-analysis

Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: a meta-analysis

Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis

The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis

Promoter –2518 single nucleotide polymorphism of monocyte chemoattractant protein-1 is associated with clinical severity in Behçet’s disease

Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population

TLR4 polymorphisms and disease susceptibility

Association of promoter region single nucleotide polymorphisms at positions −819C/T and −592C/A of interleukin 10 gene with ischemic heart disease