NDLI: Adiponectin-resistin index and its strong association with acute coronary syndrome in South Indian men

Content Provider	Springer Nature Link
Author	Singh, Prerna Sridhar, M. G. Rajappa, Medha Balachander, J. Kadhiravan, Tamilarasu
Copyright Year	2014
Abstract	India has the highest burden of acute coronary syndromes worldwide. Apart from certain lipid alterations that have been established to be definite risk factors, low level of adiponectin, high levels of resistin, and IL-6 have been shown to be risk factors for cardiovascular events. Insulin resistance is also a significant predictor of poor outcome in patients admitted with ACS.69 male patients with ACS and 70 age-matched healthy males were recruited in the study. Insulin, total adiponectin, resistin, and IL-6 levels were assayed in all study subjects. Indices of insulin resistance and novel adipokine indices were calculated using standard formulae. Multiple logistic regression analysis was done to find out the best predictor of ACS.Resistin, IL-6, insulin resistance indices, AR index, and IRAR index were found to be significantly higher, while insulin sensitivity indices and total adiponectin were found to be lower in cases, as compared with controls (p < 0.001). Insulin resistance was found to be higher in the admission sample, when compared to the fasting sample in patients with ACS (p = 0.01). On multivariate logistic regression analysis, HOMA-IR and AR index were found to be significantly associated with ACS. AR index was the best independent predictor of ACS, with the highest odds ratio (AR index: adjusted OR 17.528, p < 0.0001 versus HOMA-IR: adjusted OR 1.146, p = 0.001).The present results implicate that adipokines are significantly associated with pathogenesis of ACS, warranting adequate and early appropriate treatment to reverse this metabolic dysregulation. In our study, AR index was the best predictor of ACS. Hence, the novel AR index might be useful in routine clinical practice for screening persons with increased risk of future development of ACS.
Starting Page	961
Ending Page	968
Page Count	8
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	63
Issue Number	11
e-ISSN	1420908X
Language	English
Publisher	Springer Basel
Publisher Date	2014-09-14
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Acute coronary syndrome Adipokines Insulin resistance Immunology Pharmacology/Toxicology Rheumatology Allergology Dermatology Neurology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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