NDLI: Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice

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Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice

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Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice

Content Provider	Springer Nature Link
Author	Lee, In Ah Bae, Eun Ah Lee, Jung Hee Lee, Hoyong Ahn, Young Tae Huh, Chul Sung Kim, Dong Hyun
Copyright Year	2009
Abstract	To investigate the mechanisms of the preventive activity of lactic acid bacteria in colitis, the inhibitory effect of Bifidobacterium longum HY8004, which potently inhibited lipid peroxidation in vitro, was examined in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitic mice.We measured the ability of lactic acid bacteria (LAB) to inhibit lipid peroxidation in vitro and to inhibit colitis outcomes, colon shortening, and myeloperoxidase activity in TNBS-induced colitis in C3H/HeN and C3H/HeJ mice. We also measured levels of the inflammatory markers interleukin (IL)-1β and tumor necrosis factor (TNF)-α and their transcription factor, NF-κB, in the colon by enzyme-linked immunosorbent assay and immunoblot analysis.Among the LAB tested, B. logum HY8004 most potently inhibited lipid peroxidation in vitro but did not inhibit TLR-4-linked NF-κB activation in HEK cells. Oral administration of HY8004 inhibited TNBS-induced colon shortening and myeloperoxidase activity in the colon of C3H/HeN and C3H/HeJ mice as well as IL-1β and TNF-α expression. B. longum HY8004 also inhibited TNBS-induced lipid peroxidation, TLR-4 expression, and NF-κB activation in the colon of C3H/HeN and C3H/HeJ mice.B. longum HY8004 can improve colitis via the inhibition of lipid peroxidation as well as NF-κB activation.
Starting Page	359
Ending Page	368
Page Count	10
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	59
Issue Number	5
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2009-11-01
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bifidobacterium longum Inflammatory bowel disease 2,4,6-trinitrobenzene sulfonic acid Lipid peroxidation Toll-like receptor-4 NF-κB Neurology Dermatology Allergology Rheumatology Pharmacology/Toxicology Immunology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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