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Granulocyte Colony Stimulating Factor (G-CSF) Attenuates 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-induced Colitis in Mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Choi, Eun Young Jun, Chang-Duk Oh, Jae Min Lee, Soo Teik Kim, Sang Wook |
| Copyright Year | 2006 |
| Abstract | Granulocyte colony stimulating factor (G-CSF) is known as a cytokine central to the hematopoiesis of blood cells and to modulate their cellular functions. Besides granulocytes and their precursors, monocytes/macrophages and endothelial cells are direct target cells of G-CSF action. G-CSF influences immune cells in an anti inflammatory way. Methods: To evaluate whether G-CSF has a potential for preventing or ameliorating diseases characterized by mucosal inflammation, we used a mouse model with trinitrobenzene sulfonic acid (TNBS)-induced inflammatory colitis. To the mice model G-CSF was administrated daily by intraperitoneal injection. Macroscopic evaluation and immunohistochemical analysis of colonic tissues were performed. Results: Re combinant human G-CSF significantly inhibited LPS-induced TNF-α mRNA expression in THP-1 cells. As for in vivo relevance, G-CSF dramatically reduced the weight loss of mice, colonic damage, and mucosal ulceration that characterize TNBS colitis. Moreover, G-CSF suppressed the expression of tumor necrosis factor-α, interleukin-1β, and intercellular adhesion molecule-1 in TNBS colitis. Conclusion: Current results demonstrate that G-CSF may be an effective agent for the treatment of diseases characterized by mucosal inflammation. |
| Starting Page | 13 |
| Ending Page | 19 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Volume Number | 6 |
| Alternate Webpage(s) | https://synapse.koreamed.org/Synapse/Data/PDFData/0078IN/in-6-13.pdf |
| Alternate Webpage(s) | https://doi.org/10.4110/in.2006.6.1.13 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
