NDLI: Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells

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Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells

Content Provider	Springer Nature Link
Author	Möller, B. Kukoc Zivojv, N. Koyama, N. Grapenthin, S. Kessler, U. Klein, S. A. Kalina, U. Kaltwasser, J. P. Hoelzer, D. Ottmann, O. G.
Copyright Year	2002
Abstract	Objective: Interleukin (IL)-18 is involved in host defense mechanisms and inflammatory diseases, among them rheumatoid arthritis (RA). High levels of IL-18 expression in RA joints are contrasted by reduced IL-18 expression in RA peripheral blood mononuclear cells (PBMC). Here, we investigated a putative IL-18 regulating role of corticosteroids.¶Methods: IL-18 transcript and protein levels in PBMC from untreated and prednisolone treated RA patients, and from healthy donors were assessed by semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) and immunoblotting. IL-18 regulation was determined in PBMC and U937 cells upon exposure to prednisolone in vitro by RT-PCR and Northern Blot analysis, by ELISA in cell culture supernatants, and in transiently transfected THP-1 cells by IL-18 promoter activity luciferase assays.¶Results: In RA PBMC, IL-18 transcript levels were dose dependently restored, in parallel with administered prednisolone treatment, to subnormal levels. The corresponding intracellular IL-18 deposits in contrast were depleted. In cultured PBMC and promonocytic cell lines, prednisolone up-regulated IL-18 transcription in parallel with increasing the IL-18 protein release into cell culture supernatants.¶Conclusion: Prednisolone increases IL-18 expression and release in PBMC and monocytic cell lines.
Starting Page	457
Ending Page	463
Page Count	7
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	51
Issue Number	9
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser Verlag
Publisher Date	2002-09-01
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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