NDLI: Decreased interleukin-18 expression in BAL cells and peripheral blood mononuclear cells in adult cystic fibrosis patients.

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Decreased interleukin-18 expression in BAL cells and peripheral blood mononuclear cells in adult cystic fibrosis patients.

Content Provider	Semantic Scholar
Author	Hauber, Hans-Peter Beyer, Inga S. Meyer, Andreas Pforte, Almuth
Copyright Year	2004
Abstract	Lymphocytes from cystic fibrosis (CF) patients secrete less interferon-gamma (IFN-gamma) upon stimulation compared to controls. Expression of interleukin (IL)-18 as an IFN-gamma inducing factor and of IL-10 as an IL-18 inhibiting factor were determined in bronchoalveolar lavage (BAL) cells from CF patients (n=5) and from normal control subjects (n=9) as well as in peripheral blood mononuclear cells (PBMC) from patients (n=12) and from control subjects (n=9) with RT-PCR. IL-18 and IL-10 serum protein levels were measured using ELISA. BAL cells and PBMC of CF patients expressed significantly less IL-18 compared to controls (p<0.05). There was no significant difference for IL-10 in BAL cells. However, PBMC from patients expressed significantly more IL-10 mRNA (p<0.05). IL-18 serum protein levels were decreased in the patient group, whereas IL-10 serum concentrations were elevated. Stimulation with rhIL-10 reduced IL-18 expression in PBMC from CF patients. Decreased IL-18 expression in CF patients may contribute to decreased IFN-gamma production. IL-10 may contribute to inhibit IL-18 expression in PBMC in CF.
File Format	PDF HTM / HTML
DOI	10.1016/j.jcf.2004.03.006
PubMed reference number	15463896
Journal	Medline
Volume Number	3
Issue Number	2
Alternate Webpage(s)	https://core.ac.uk/download/pdf/82818486.pdf
Journal	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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