NDLI: Clinical Use and Therapeutic Potential of IVIG/SCIG, Plasma-Derived IgA or IgM, and Other Alternative Immunoglobulin Preparations

Content Provider	Springer Nature Link
Author	Späth, Peter J. Schneider, Christoph von Gunten, Stephan
Copyright Year	2016
Abstract	Intravenous and subcutaneous immunoglobulin preparations, consisting of IgG class antibodies, are increasingly used to treat a broad range of pathological conditions, including humoral immune deficiencies, as well as acute and chronic inflammatory or autoimmune disorders. A plethora of Fab- or Fc-mediated immune regulatory mechanisms has been described that might act separately or in concert, depending on pathogenesis or stage of clinical condition. Attempts have been undertaken to improve the efficacy of polyclonal IgG preparations, including the identification of relevant subfractions, mild chemical modification of molecules, or modification of carbohydrate side chains. Furthermore, plasma-derived IgA or IgM preparations may exhibit characteristics that might be exploited therapeutically. The need for improved treatment strategies without increase in plasma demand is a goal and might be achieved by more optimal use of plasma-derived proteins, including the IgA and the IgM fractions. This article provides an overview on the current knowledge and future strategies to improve the efficacy of regular IgG preparations and discusses the potential of human plasma-derived IgA, IgM, and preparations composed of mixtures of IgG, IgA, and IgM.
Starting Page	215
Ending Page	231
Page Count	17
File Format	PDF
ISSN	0004069X
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume Number	65
Issue Number	3
e-ISSN	16614917
Language	English
Publisher	Springer International Publishing
Publisher Date	2016-09-16
Publisher Place	Cham
Access Restriction	Subscribed
Subject Keyword	Immunoglobulin preparations SCIG IVIG Polyclonal IgG Polyclonal IgA Polyclonal IgM Host defence Immunomodulation Immunology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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