NDLI: Serum Tumor Necrosis Factor-α and Interleukin-10 Levels as Markers to Predict Outcome of Patients with Chronic Lymphocytic Leukemia in Different Risk Groups Defined by the IGHV Mutation Status

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Serum Tumor Necrosis Factor-α and Interleukin-10 Levels as Markers to Predict Outcome of Patients with Chronic Lymphocytic Leukemia in Different Risk Groups Defined by the IGHV Mutation Status

Generation of Functional T-Regulatory Cells in Children with Metabolic Syndrome

Archivum Immunologiae et Therapiae Experimentalis : Volume 60, Issue 5, October 2012

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Serum Tumor Necrosis Factor-α and Interleukin-10 Levels as Markers to Predict Outcome of Patients with Chronic Lymphocytic Leukemia in Different Risk Groups Defined by the IGHV Mutation Status

Content Provider	Springer Nature Link
Author	Lech Maranda, Ewa Grzybowska Izydorczyk, Olga Wyka, Krystyna Mlynarski, Wojciech Borowiec, Maciej Antosik, Karolina Cebula Obrzut, Barbara Makuch Lasica, Hanna wak, Grazyna Klimkiewicz Wojciechowska, Gabriela Wawrzyniak, Ewa Bilinski, Przemyslaw Robak, Tadeusz Warzocha, Krzysztof
Copyright Year	2012
Abstract	Tumor necrosis factor (TNF)-α and interleukin (IL)-10 are cytokines involved in the balance between cell-mediated and humoral immunity. We investigated whether serum TNF-α and IL-10 levels have any impact on clinical outcome of patients with chronic lymphocytic leukemia (CLL). TNF-α and IL-10 levels were determined in the serum of 160 CLL patients at the time of diagnosis. The cytokine low-risk group consisted of patients with either TNF-α and IL-10 levels below their medians or those with only one elevated parameter. Both TNF-α and IL-10 levels greater than or equal to their medians defined the cytokine high-risk group. The high-risk patients presented a shorter 3-year treatment-free survival (TFS) than low-risk subjects (15 vs. 69.6 %; p < 0.0001). The high-risk group (p = 0.0002) along with high leukocyte count (p < 0.0001) and unmutated immunoglobulin heavy-chain variable region genes (p < 0.0001) independently predict the risk of progression in patients with Rai stage 0–II. Furthermore, the high-risk group had an independent prognostic impact on shorter TFS both in patients with mutated (24.3 vs. 78.2 %; p < 0.0001) and unmutated (8.2 vs. 49 %; p = 0.004) immunoglobulin heavy-chain variable region genes (IGHV) as compared to the low-risk group. The estimated 5-year overall survival (OS) of high-risk patients was shorter than those in the low-risk group (83.3 vs. 97.1 %; p = 0.003). Multivariate analysis demonstrated the cytokine high-risk group (p = 0.02) followed by Rai stage III–IV (p = 0.048) to be independent factors predicting shorter OS. At diagnosis, TNF-α and IL-10 may predict the outcome of patients with CLL.
Starting Page	477
Ending Page	486
Page Count	10
File Format	PDF
ISSN	0004069X
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume Number	60
Issue Number	6
e-ISSN	16614917
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2012-09-04
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Chronic lymphocytic leukemia Tumor necrosis factor-α Interleukin-10 Immunoglobulin heavy-chain variable region genes Outcome Pharmacology/Toxicology Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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