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Effect of Sidr (Zizyphus spina-christi) fruit extract on the central nervous system in male albino rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Waggas, Abeer M. Alhasani, Reem Hasaballah A. |
| Copyright Year | 2009 |
| Abstract | Sidr (Zizyphus spina-christiL ) is medicinal plant with many traditional uses. The aim of the present study is to investigate the chronic effect of Sidr (Zizyphus spina-christiL ) fruit extract on norepinephrin (NE), dopamine (DA), serotonin (5-HT) and gamma-aminobutyric acid (GABA) content in different brain areas (cerebellum, brain stem, striatum, cerebral cortex, hypothalamus and hippocampus ) of male albino rat. The daily i.p. administration of Sidr fruit extract ( 50mg/kg body wt ) for 3 weeks caused a significant decrease in neurotransmitter content in all the tested brain areas at most of the time intervals studies. This may be to the presence of ascorbic acid which caused neurotransmitter release from presynaptic by enhanced Ca2+ influx and the content is decreased, also ascorbic acid increase in nitric oxide (NO) levels so the content of neurotransmitter is decreased. |
| Starting Page | 263 |
| Ending Page | 267 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Volume Number | 4 |
| Alternate Webpage(s) | http://www.idosi.org/aejsr/4(4)09/8.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
