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Effect of Glibenclamide and Fruit extract of Zizyphus spina-christi on Alloxan- induced Diabetic Dogs
| Content Provider | Semantic Scholar |
|---|---|
| Author | Avizeh, Reza Najafzadeh, Hossein Pourmahdi, Mahdi Mirzaee, M. |
| Copyright Year | 2010 |
| Abstract | In traditional medicine, several plants have been used for diabetes treatment. However, the antidiabetic activity of the fruits of Zizyphus spina-christi had never been investigated in experimental diabetic dogs. Twelve adult dogs were divided into three equal groups each one consisting of four dogs. One was the diabetic control, the second was the glibenclamide treated, and the other was the Zizyphus extract treated group. The present study aimed to test the 10 days oral administration of Z. spina-christi fruit hydroalcoholic extract (500 mg/kg) for its effects in alloxan-induced diabetic dogs in comparison with glibenclamide (0.2 mg/kg) antidiabetic activity. The results showed that treatment with glibenclamide nonsignificant ly reduced the blood glucose level (p > 0.05) and significantly increased the serum insulin level of diabetic dogs (p < 0.05). In contrast to glibenclamide, the hydroalcoholic extract of Z. spina-christi resulted in a significant decrease in the level of blood glucose, with a concomitant significant increase in the serum insulin level, in diabetic dogs (p < 0.05). The extract had a mild, but significant, blood glucose lowering effect and the longterm use of this agent may be advantageous over chemical drugs in alleviating some of the chronic diseases and complications caused by diabetes. |
| Starting Page | 109 |
| Ending Page | 113 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Volume Number | 8 |
| Alternate Webpage(s) | http://www.jarvm.com/articles/Vol8Iss2/Vol8%20Iss2avizeh.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
